Evaluation of Biocompatibility and Bioactivity for Polymethyl Methacrylate – Bioactive Glass Nanocomposite Films Obtained Bymatrix Assisted Pulsed Laser Evaporation
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چکیده
Noi am evaluat rezistenţa la zgâriere, aderenţa şi duritatea pentru un nou compozit: polimetil metacrilat biosticlă (PMMA+BG) depus prin tehnica evaporării laser pulsate asistate de o matrice, pe substrat de titan de grad medical, pentru aplicaţii în implantologie. Bioactivitatea filmelor a fost evaluată in vitro prin imersia lor în fluid uman simulat (SBF) pentru diferite perioade de timp, urmată de analize de spectrosie îninfraroşu cu transformată Fourieri de microscopie confocală cu scanare laser, pentru a determina formarea hidroxiapatitei pe suprafaţa bioactivă. Interacţiunea dintreosteoblaste umane şi materialul testat a fost studiată prin marcarea fluorescentă a proteinelor celulare: actina şi vinculina. Osteoblastele umane au arătat că acoperă întreaga structură, cu care interacţionează puternic, ceea ce e o dovadă a biocompatibilităţii filmelor de PMMA+GB.
منابع مشابه
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تاریخ انتشار 2010